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Targeted Allele Detail
Symbol: Egfrtm1Wag
Name: epidermal growth factor receptor; targeted mutation 1, Erwin F Wagner
MGI ID: MGI:1935108
Synonyms: EGFR-
Gene: Egfr  Location: Chr11:16752203-16913907 bp, + strand  Genetic Position: Chr11, 9.41 cM, cytoband A1-A4
Germline Transmission:  Earliest citation of germline transmission: J:26834
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of the first exon was replaced by an in frame lacZ gene, followed by either a neomycin or a hygromycin selection cassette. These two different constructs were used to generate separate lines of mice, but the analysis did not distinguish between them. An EGFR-beta-galactosidase fusion protein was produced from this allele that was expressed under the control of the endogenous gene promoter. (J:26834)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Egfr Mutation:  14 strains or lines available
Original:  J:26834 Sibilia M, et al., Strain-dependent epithelial defects in mice lacking the EGF receptor [published erratum appears in Science 1995 Aug 18;269(5226):909]. Science. 1995 Jul 14;269(5221):234-8
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory