Summary |
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Mutation origin |
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Mutation description |
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Find Mice (IMSR) |
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Notes |
This allele determines high preference for saccharin (0.1% solution) over water (J:5474), and is present in the following strains: C57BL/6 substrains, SWR, FVB, and ST/bJ. The allele is selectively expressed in taste receptor cells. The mechanism of preference is predicted to be related to the incentive value of the taste of saccharin rather than to the threshold for detection (J:5474).
Preference for other sweeteners (acesulfame, dulcin, and sucrose) across a panel of 26 inbred strains showed a high correlation with saccharin preference, suggesting the existence of a single receptor for sweetness (J:9874). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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