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Targeted Allele Detail
Symbol: Prnptm1Miy
Name: prion protein; targeted mutation 1, Tsutomu Miyamoto
MGI ID: MGI:1934272
Synonyms: Nagasaki, Ngsk Prnp0, Prnp-, PrP
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Germline Transmission:  Earliest citation of germline transmission: J:69186
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding sequence of the gene was replaced with a neomycin cassette. No mRNA was detected in the brains of homozyogous mutant mice by either Northern blotting or by in situ hybridization. (J:69186)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  95 strains or lines available
Original:  J:69186 Sakaguchi S, et al., Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent. J Virol. 1995 Dec;69(12):7586-92
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory