Prnptm1Miy
Targeted Allele Detail
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Symbol: |
Prnptm1Miy |
Name: |
prion protein; targeted mutation 1, Tsutomu Miyamoto |
MGI ID: |
MGI:1934272 |
Synonyms: |
Nagasaki, Ngsk Prnp0, Prnp-, PrP |
Gene: |
Prnp Location: Chr2:131909928-131938429 bp, + strand Genetic Position: Chr2, 64.07 cM
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Germline Transmission: |
Earliest citation of germline transmission:
J:69186
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The entire coding sequence of the gene was replaced with a neomycin cassette. No mRNA was detected in the brains of homozyogous mutant mice by either Northern blotting or by in situ hybridization.
(J:69186)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Prnp Mutation: |
88 strains or lines available
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Original: |
J:69186 Sakaguchi S, et al., Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent. J Virol. 1995 Dec;69(12):7586-92 |
All: |
23 reference(s) |
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