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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prnptm1Miy
targeted mutation 1, Tsutomu Miyamoto
MGI:1934272
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prnptm1Miy/Prnptm1Miy involves: 129S4/SvJae * C57BL/6 MGI:2174711


Genotype
MGI:2174711
hm1
Allelic
Composition		 Prnptm1Miy/Prnptm1Miy
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prnptm1Miy mutation (0 available); any Prnp mutation (143 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to prion infection ( J:69186 )
• resistance to scrapie infection

behavior/neurological
ataxia ( J:32440 )
• after 70 weeks of age
impaired coordination ( J:32440 )
• after 70 weeks of age

nervous system
Purkinje cell degeneration ( J:32440 )
• after 70 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT Creutzfeldt-Jakob disease DOID:11949 OMIM:123400
 J:69186




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory