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Targeted Allele Detail
Symbol: Cxcr4tm1Qma
Name: chemokine (C-X-C motif) receptor 4; targeted mutation 1, Qing Ma
MGI ID: MGI:1934166
Synonyms: CXCR4-
Gene: Cxcr4  Location: Chr1:128588199-128592293 bp, - strand  Genetic Position: Chr1, 56.43 cM
Abnormal neuronal cell migration in Cxcr4tm1Qma/Cxcr4tm1Qma cerebellum

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:49070
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced sequences in exon 2 that encode the fourth transmembrane domain and a portion of the third extracellular domain. RT-PCR studies did not detect transcript in homozygous brain. (J:49070)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 27 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cxcr4 Mutation:  29 strains or lines available
Original:  J:49070 Ma Q, et al., Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9448-53
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory