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Cr2tm1Crr
Targeted Allele Detail
Nomenclature
Symbol: Cr2tm1Crr
Name: complement receptor 2; targeted mutation 1, Michael C Carroll
MGI ID: MGI:1933715
Synonyms: Cr2-, Cr2def
Gene: Cr2  Location: Chr1:195136811-195176716 bp, - strand  Genetic Position: Chr1, 98.44 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31942
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin resistance cassette into short consensus repeat (SCR) 10 disrupted the gene by introducing a frameshift mutation and a stop codon. Immunohistochemical staining and flow cytometric analysis detected negligible expression in splenic B cells of homozygous mutant mice. (J:31942)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cr2 Mutation:  33 strains or lines available
References
Original:  J:31942 Ahearn JM, et al., Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity. 1996 Mar;4(3):251-62
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory