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Zp3tm1Pmw
Targeted Allele Detail
Nomenclature
Symbol: Zp3tm1Pmw
Name: zona pellucida glycoprotein 3; targeted mutation 1, Paul W Wasserman
MGI ID: MGI:1932681
Synonyms: mZP3-
Gene: Zp3  Location: Chr5:135980099-135988624 bp, + strand  Genetic Position: Chr5, 75.62 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33254
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 2, intron 2 and exon 3 were replaced by a pGK-neomycin cassette. Homozygous mutant female mice were analyzed by Northern and Western blotting to establish that the mRNA and protein were not present in growing oocytes. (J:33254)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zp3 Mutation:  25 strains or lines available
References
Original:  J:33254 Liu C, et al., Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5431-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory