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Xrcc1tm1Rpe
Targeted Allele Detail
Summary
Symbol: Xrcc1tm1Rpe
Name: X-ray repair complementing defective repair in Chinese hamster cells 1; targeted mutation 1, Roger A Pedersen
MGI ID: MGI:1932097
Synonyms: Xrcc1-
Gene: Xrcc1  Location: Chr7:24246124-24272863 bp, + strand  Genetic Position: Chr7, 11.42 cM, cytoband A3-B2
Alliance: Xrcc1tm1Rpe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54226
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a neomycin resistance cassette into exon 8 disrupted the Xrcc1 gene and replaced 8bp of coding sequence. Western blot analysis did not detect XRCC1 protein or truncation products in total protein extracts from cell lines made from 8.5 day embryos that were homozygous for both Xrcc1tm1Rpe and Trp53tm1Tyj. (J:54226)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Xrcc1 Mutation:  45 strains or lines available
References
Original:  J:54226 Tebbs RS, et al., Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev Biol. 1999 Apr 15;208(2):513-29
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory