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Nr3c1tm2.1Gsc
Targeted Allele Detail
Nomenclature
Symbol: Nr3c1tm2.1Gsc
Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 2.1, Gunther Schutz
MGI ID: MGI:1931328
Synonyms: GRN-, GRnull
Gene: Nr3c1  Location: Chr18:39410545-39491301 bp, - strand  Genetic Position: Chr18, 21.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54931
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele is a derivative of Nr3c1tm2Gsc in which loxP sites were inserted to flank exon 3. Transient Cre expression in ES cells was used to deletion the third exon. (J:54931)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:  12 strains or lines available
References
Original:  J:54931 Finotto S, et al., Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development. 1999 Jul;126(13):2935-44
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory