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Targeted Allele Detail
Symbol: Nr3c1tm2.1Gsc
Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 2.1, Gunther Schutz
MGI ID: MGI:1931328
Synonyms: GRN-, GRnull
Gene: Nr3c1  Location: Chr18:39410545-39519421 bp, - strand  Genetic Position: Chr18, 21.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:54931
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele is a derivative of Nr3c1tm2Gsc in which loxP sites were inserted to flank exon 3. Transient Cre expression in ES cells was used to deletion the third exon. (J:54931)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:  21 strains or lines available
Original:  J:54931 Finotto S, et al., Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells. Development. 1999 Jul;126(13):2935-44
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory