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Targeted Allele Detail
Symbol: Nr3c1tm2Gsc
Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 2, Gunther Schutz
MGI ID: MGI:1931327
Synonyms: GR-, GRflox, Grl1loxP, Grl1tm2Gsc, GRlox, GRloxP
Gene: Nr3c1  Location: Chr18:39410545-39491301 bp, - strand  Genetic Position: Chr18, 21.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:57315
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of loxP sites flanking exon 3. A loxP flanked neomycin/thymidine kinase cassette in intron 3 was removed by transient expression of Cre recombinase in ES cells prior to blastocyst injection. (J:57315)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:  12 strains or lines available
Phenotypic Similarity to Human Syndrome: Cushing Syndrome with loss of expression in the nervous system (crossed to Tg(Nes-cre)1Kln) (J:57315)
Original:  J:57315 Tronche F, et al., Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet. 1999 Sep;23(1):99-103
All:  60 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.09
The Jackson Laboratory