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Targeted Allele Detail
Symbol: Lpar1tm1Jch
Name: lysophosphatidic acid receptor 1; targeted mutation 1, Jerod Chun
MGI ID: MGI:1931154
Synonyms: lpa1-, LPA1-null, Lpar1-
Gene: Lpar1  Location: Chr4:58435255-58553898 bp, - strand  Genetic Position: Chr4, 32.2 cM
Gross abnormalities in Lpar1tm1Jch/Lpar1tm1Jch mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:65882
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsLoxP sites that flanked exon 3 were inserted by homologous recombination. The loxP-flanked sequences were then deleted by transient cre mediated recombination in ES cells prior to the production of chimeric animals. No mRNA was detected in adult brain derived from homozygous mice. (J:65882)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lpar1 Mutation:  48 strains or lines available
Original:  J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory