Myl1^tm1(cre)Sjb
Targeted Allele Detail

Summary

• Symbol: Myl1^tm1(cre)Sjb
• Name: myosin, light polypeptide 1; targeted mutation 1, Steven J Burden
• MGI ID: MGI:1931135
• Synonyms: Mlc1f-cre, mlc^cre, MLC-Cre, Mlcf-cre
• Gene: Myl1 Location: Chr1:66963454-66984563 bp, - strand Genetic Position: Chr1, 33.71 cM
• Alliance: Myl1^tm1(cre)Sjb page

Skeletal muscle analysis of Tfam^tm1Lrsn/Tfam^tm1Lrsn Myl1^tm1(cre)Sjb/Myl1⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67675
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Myl1^tm1(cre)Sjb expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myl1 (MGI:97269)

• Mutation details: Insertion of an NLS-cre gene into exon 1, immediately upstream of the initiator ATG. An adjacent lox-P flanked neomycin cassette was removed by Cre mediated recombination in the final allele. (J:67675)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myl1 (mouse) Summary of all recombinase alleles driven by Myl1. Alliance mouse Myl1 gene page

Disease models

Expression

In Mice Carrying this Mutation:

9 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myl1 Mutation: 17 strains or lines available

References

• Original: J:67675 Bothe GW, et al., Selective expression of Cre recombinase in skeletal muscle fibers. Genesis. 2000 Feb;26(2):165-6
• All: 121 reference(s)