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Phenotype Image Detail
Caption Analysis of tissue sections from extensor digitorum longus (EDL) muscle from Tfamtm1Lrsn/Tfamtm1Lrsn Myl1tm1(cre)Sjb/Myl1+ mouse (A-C) and a control (D-F) mouse at 3 months of age. A & D: Hematoxylin and eosin staining. There are scattered atrophic fibers in the mutant mouse. B & E: Modified Gomori trichrome staining. There are numerous ragged red muscle fibers (RRFs) in the mutant mouse. C & F: Staining to detect simultaneous cytochrome c oxidase (COX)/succinate dehydrogenase (SDH) activity. The muscle fibers that appear blue in the mutant mouse are COX deficient and contain accumulation of mitochondria. Scale bar, 25um
Copyright This image is from Wredenberg A, Proc Natl Acad Sci U S A 2002 Nov 12;99(23):15066-71. Copyright 2002 National Academy of Sciences, U.S.A. J:81561
Symbol Name
Myl1tm1(cre)Sjb myosin, light polypeptide 1; targeted mutation 1, Steven J Burden
Tfamtm1Lrsn transcription factor A, mitochondrial; targeted mutation 1, Nils-Goran Larsson
Allelic Composition Genetic Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory