Ifngr2^tm1Pbro
Targeted Allele Detail

Summary

• Symbol: Ifngr2^tm1Pbro
• Name: interferon gamma receptor 2; targeted mutation 1, Paul B Rothman
• MGI ID: MGI:1930965
• Synonyms: IFN-gammaR2 -, IFNgammaRB^null, Ifngr2^tm1Cmb
• Gene: Ifngr2 Location: Chr16:91343947-91360895 bp, + strand Genetic Position: Chr16, 53.07 cM
• Alliance: Ifngr2^tm1Pbro page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48016
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of the second coding exon with a neomycin gene. (J:48016)
• Inheritance: Recessive

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ifngr2 Mutation: 23 strains or lines available

References

• Original: J:48016 Lu B, et al., Targeted disruption of the interferon-gamma receptor 2 gene results in severe immune defects in mice. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8233-8
• All: 16 reference(s)