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Targeted Allele Detail
Symbol: En2tm3.1Alj
Name: engrailed 2; targeted mutation 3.1, Alexandra L Joyner
MGI ID: MGI:1930812
Synonyms: En2pbd
Gene: En2  Location: Chr5:28165696-28172166 bp, + strand  Genetic Position: Chr5, 13.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:60433
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of two adjacent Pax-binding sites (66 bp) in the regulatory region with a lox-P flanked neomycin cassette. In this derivative of En2tm3Alj, the neomycin cassette was removed via Cre mediated recombination, leaving a loxP site in place of the Pax binding sites. (J:60433)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 11 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any En2 Mutation:  7 strains or lines available
Original:  J:60433 Li Song D, et al., Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression. Mech Dev. 2000 Feb;90(2):155-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.13
The Jackson Laboratory