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En2tm3Alj
Targeted Allele Detail
Summary
Symbol: En2tm3Alj
Name: engrailed 2; targeted mutation 3, Alexandra L Joyner
MGI ID: MGI:1930811
Synonyms: En2pbdneo
Gene: En2  Location: Chr5:28370692-28377164 bp, + strand  Genetic Position: Chr5, 13.94 cM
Alliance: En2tm3Alj page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60433
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of two adjacent Pax-binding sites (66 bp) in the regulatory region with a lox-P flanked neomycin cassette. This allele is hypomorphic for the expression of the gene. (J:60433)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any En2 Mutation:  104 strains or lines available
References
Original:  J:60433 Li Song D, et al., Two Pax2/5/8-binding sites in Engrailed2 are required for proper initiation of endogenous mid-hindbrain expression. Mech Dev. 2000 Feb;90(2):155-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory