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Brca2tm1Cam
Targeted Allele Detail
Nomenclature
Symbol: Brca2tm1Cam
Name: breast cancer 2, early onset; targeted mutation 1, University of Cambridge
MGI ID: MGI:1930616
Synonyms: Brca2Tr
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46812
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsInsertion of a beta-geo selection cassette into exon 11 and deletion of nucleotides 4668-4989. This allele expresses a truncated protein at amino acid 1492, similar to truncating mutations found in humans. (J:46812)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  33 strains or lines available
References
Original:  J:46812 Friedman LS, et al., Thymic lymphomas in mice with a truncating mutation in Brca2. Cancer Res. 1998 Apr 1;58(7):1338-43
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/08/2020
MGI 6.15
The Jackson Laboratory