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Targeted Allele Detail
Symbol: Bdnftm1Lfr
Name: brain derived neurotrophic factor; targeted mutation 1, Louis F Reichardt
MGI ID: MGI:1930110
Synonyms: BDNF-, BDNFneo
Gene: Bdnf  Location: Chr2:109674700-109727007 bp, + strand  Genetic Position: Chr2, 56.63 cM
Germline Transmission:  Earliest citation of germline transmission: J:67231
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsDeletion of a large region of the coding region and replacement with a neomycin cassette. Deleted sequences include residues required for prohomrone processing and interactions of mature neurotrophins with Trk receptors and with Ngfr. (J:67231)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bdnf Mutation:  21 strains or lines available
Original:  J:67231 Jones KR, et al., Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell. 1994 Mar 25;76(6):989-99
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory