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Notch4tm1Grid
Targeted Allele Detail
Nomenclature
Symbol: Notch4tm1Grid
Name: notch 4; targeted mutation 1, Tom Gridley
MGI ID: MGI:1929139
Synonyms: Notch4-, Notch4d1
Gene: Notch4  Location: Chr17:34564268-34588503 bp, + strand  Genetic Position: Chr17, 18.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62571
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele carries a deletion of 1.0kb of sequence containing exons 21 and 22, which encode part of the extracellular domain of the protein. (J:62571)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Notch4 Mutation:  39 strains or lines available
References
Original:  J:62571 Krebs LT, et al., Notch signaling is essential for vascular morphogenesis in mice. Genes Dev. 2000 Jun 1;14(11):1343-52
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory