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Trim28tm1.1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Trim28tm1.1Ipc
Name: tripartite motif-containing 28; targeted mutation 1.1, Pierre Chambon
MGI ID: MGI:1928907
Synonyms: Kap1fl, L2, Trim28f
Gene: Trim28  Location: Chr7:12758079-12764959 bp, + strand  Genetic Position: Chr7, 7.73 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62628
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsInsertion of loxP sites as follows: A PGK-neomycin cassette flanked by two loxP sites was introduced into intron 3 and a loxP site was introduced into intron 14. Mice positive for the presence of this allele were mated to CMV-Cre transgenic mice to generate mice in which the PGK-neomycin cassette sequences were deleted. (J:62628)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 207923 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trim28 Mutation:  31 strains or lines available
References
Original:  J:62628 Cammas F, et al., Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development. 2000 Jul;127(13):2955-63
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory