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Atmtm1Led
Targeted Allele Detail
Nomenclature
Symbol: Atmtm1Led
Name: ataxia telangiectasia mutated; targeted mutation 1, Philip Leder
MGI ID: MGI:1926875
Synonyms: Atm -
Gene: Atm  Location: Chr9:53439149-53536740 bp, - strand  Genetic Position: Chr9, 29.12 cM, cytoband C-D
Cross section through seminiferous tubule of +/+ and Atmtm1Led/Atmtm1Led mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36561
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin cassette was inserted into a coding exon of the mouse Atm gene. The insertion position corresponds to nt 5640 of the human ATM cDNA. (J:36561)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atm Mutation:  109 strains or lines available
References
Original:  J:36561 Elson A, et al., Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13084-9
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/03/2018
MGI 6.11
The Jackson Laboratory