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Atmtm1Led
Targeted Allele Detail
Summary
Symbol: Atmtm1Led
Name: ataxia telangiectasia mutated; targeted mutation 1, Philip Leder
MGI ID: MGI:1926875
Synonyms: Atm -
Gene: Atm  Location: Chr9:53350449-53448040 bp, - strand  Genetic Position: Chr9, 29.12 cM, cytoband C-D
Alliance: Atmtm1Led page
Cross section through seminiferous tubule of +/+ and Atmtm1Led/Atmtm1Led mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36561
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA PGK-neomycin cassette was inserted into a coding exon of the mouse Atm gene. The insertion position corresponds to nt 5640 of the human ATM cDNA. (J:36561)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 5 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Atmtm1Led
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atm Mutation:  126 strains or lines available
References
Original:  J:36561 Elson A, et al., Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13084-9
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory