About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atmtm1Led
targeted mutation 1, Philip Leder
MGI:1926875
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atmtm1Led/Atmtm1Led involves: 129S6/SvEvTac * Black Swiss MGI:2175708
cx2
Atmtm1Led/Atm+
Kat8tm2Thl/Kat8+
involves: 129S1/Sv * 129S6/SvEvTac MGI:3769385
cx3
Atmtm1Led/Atmtm1Led
Kat8tm2Thl/Kat8+
involves: 129S1/Sv * 129S6/SvEvTac MGI:3769386


Genotype
MGI:2175708
hm1
Allelic
Composition
Atmtm1Led/Atmtm1Led
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation (0 available); any Atm mutation (126 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cross section through seminiferous tubule of +/+ and Atmtm1Led/Atmtm1Led mice

mortality/aging
• 100% mortality by 40 weeks of age

growth/size/body

immune system
• fourfold decrease in CD4+CD8- single positive cells

reproductive system
• lack of maturing sperm within the seminiferous tubules and of mature sperm in the tubule lumen, the epididymis, and ductus deferens
• testes were structurally abnormal

neoplasm
• mostly of double positive T cells
• some develop malignant thymomas between 3 and 4 months of age

cellular
• 3 fold increase in radiation induced chromosomal aberrations
• lack of maturing sperm within the seminiferous tubules and of mature sperm in the tubule lumen, the epididymis, and ductus deferens
• increased sensitivity of thymocytes and splenocytes to ionizing radiation
• fibroblasts exhibited nearly 6.5-fold more chromosomal breaks per metaphase than controls

nervous system
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 days
• survival of cultured cells improves if cultured with cerebellar astroglial cell
• develop simpler dendritic arboritization with reduced secondary branching
• nitroxide free radicals improve survival and arborization

endocrine/exocrine glands
• testes were structurally abnormal
• mostly of double positive T cells

hematopoietic system
• fourfold decrease in CD4+CD8- single positive cells

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
ataxia telangiectasia DOID:12704 OMIM:208900
J:36561




Genotype
MGI:3769385
cx2
Allelic
Composition
Atmtm1Led/Atm+
Kat8tm2Thl/Kat8+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation (0 available); any Atm mutation (126 available)
Kat8tm2Thl mutation (0 available); any Kat8 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 76% of mice survive the first year




Genotype
MGI:3769386
cx3
Allelic
Composition
Atmtm1Led/Atmtm1Led
Kat8tm2Thl/Kat8+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation (0 available); any Atm mutation (126 available)
Kat8tm2Thl mutation (0 available); any Kat8 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die earlier than Atmtm1Led homozygotes

growth/size/body
• mice exhibit a modest reduction in weight compared to Atmtm1Led homozygotes





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/17/2023
MGI 6.22
The Jackson Laboratory