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Targeted Allele Detail
Symbol: Stat3tm2Aki
Name: signal transducer and activator of transcription 3; targeted mutation 2, Shizuo Akira
MGI ID: MGI:1926816
Synonyms: Stat3cKO, Stat3flox, Stat3flx, STAT3lox, Stat3loxP, STAT3-loxP
Gene: Stat3  Location: Chr11:100886806-100939594 bp, - strand  Genetic Position: Chr11, 63.82 cM
Germline Transmission:  Earliest citation of germline transmission: J:50443
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsInsertion of loxP sites flanking exons encoding the tyrosine phosphorylation site. No phenotypic effect on the function of the Stat3 gene. (J:50443)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  35 strains or lines available
Original:  J:50443 Takeda K, et al., Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol. 1998 Nov 1;161(9):4652-60
All:  221 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory