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Stat3tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Stat3tm1Aki
Name: signal transducer and activator of transcription 3; targeted mutation 1, Shizuo Akira
MGI ID: MGI:1926814
Synonyms: Stat3-
Gene: Stat3  Location: Chr11:100885098-100939540 bp, - strand  Genetic Position: Chr11, 63.82 cM
Histological analysis of wild type and Stat3tm1Aki/Stat3tm1Aki embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40106
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced 3.0kb of sequence containing exons 20-22. (J:40106)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:  29 strains or lines available
References
Original:  J:40106 Takeda K, et al., Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3801-4
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory