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Targeted Allele Detail
Symbol: Itgb1tm1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Reinhard Fassler
MGI ID: MGI:1926498
Synonyms: beta1fl, beta1 integrin (fl), floxed beta1 integrin
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Hair and skin phenotypes of various keratinocyte conditional Itgb1 alleles

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:78985
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 2 through 7 were flanked by single loxP sites in intron 1 and intron 8. The construct included a promoterless LacZ reporter gene introduced after the downstream loxP site, enabling the detection of cre mediated recombination by lacZ expression. Northern blot analysis demonstrated that expression of the floxed allele was unaffected by the presence of the loxP sites. (J:78985)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  26 strains or lines available
Phenotypic Similarity to Human Syndrome: Hirschsprung disease in mice heterozygous for Itgb1tm1Lscd and Itgb1tm1Ref and hemizygous for Tg(PLAT-cre)116Sdu (J:108439)

Original:  J:78985 Potocnik AJ, et al., Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity. 2000 Jun;12(6):653-63
All:  49 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory