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Itgb1tm1Ref
Targeted Allele Detail
Nomenclature
Symbol: Itgb1tm1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1, Reinhard Fassler
MGI ID: MGI:1926498
Synonyms: beta1fl, beta1 integrin (fl), floxed beta1 integrin
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Hair and skin phenotypes of various keratinocyte conditional Itgb1 alleles

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:78985
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  14 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Hirschsprung disease in mice heterozygous for Itgb1tm1Lscd and Itgb1tm1Ref and hemizygous for Tg(PLAT-cre)116Sdu (J:108439)

References
Original:  J:78985 Potocnik AJ, et al., Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow. Immunity. 2000 Jun;12(6):653-63
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory