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Targeted Allele Detail
Symbol: Chrna4tm1Jpc
Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, Jean-Pierre Changeux
MGI ID: MGI:1926251
Synonyms: alpha4 -
Gene: Chrna4  Location: Chr2:181022311-181043579 bp, - strand  Genetic Position: Chr2, 103.54 cM
Germline Transmission:  Earliest citation of germline transmission: J:54505
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe 5' portion of exon 5 (encoding three of the four putative transmembrane spanning domains and the acetylcholine binding site) and 400 base pairs of the upstream intron sequence were replaced with a neomycin resistance gene. (J:54505)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chrna4 Mutation:  29 strains or lines available
Original:  J:54505 Marubio LM, et al., Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature. 1999 Apr 29;398(6730):805-10
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory