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Targeted Allele Detail
Symbol: Prnptm1Cwe
Name: prion protein; targeted mutation 1, Charles Weissmann
MGI ID: MGI:1888773
Synonyms: Prnp-, Prn-p0, Prnp0, Prnp0 Zurich I, Prnptm1ZH1, Prnptm1Zrch, Prnp trn1Zrch, PrnpZH1, PrP0, PrPC-KO, PrPC Zrch-1, Zrch 1 Prnp0, ZrchI Prnp-, Zrch Prnp0, Zurich line
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Tg(Prnp*S170N*N174T)1020Aag/0 Prnptm1Cwe/Prnptm1Cwe mice develop a lethal neurologic disease with lesions in the brain and muscle

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:472
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 552 bp fragment of the coding region contained within exon 3 was replaced with a 1.1 kb cassette containing the TK promoter followed by the neomycin gene. (J:472, J:83401)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 43 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 32 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  95 strains or lines available
Original:  J:472 Bueler H, et al., Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein [see comments]. Nature. 1992 Apr 16;356(6370):577-82
All:  279 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory