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Timp2tm1Pds
Targeted Allele Detail
Nomenclature
Symbol: Timp2tm1Pds
Name: tissue inhibitor of metalloproteinase 2; targeted mutation 1, Paul D Soloway
MGI ID: MGI:1888708
Synonyms: Timp2-, TIMP2KO, TIMP-2KO
Gene: Timp2  Location: Chr11:118301069-118355740 bp, - strand  Genetic Position: Chr11, 83.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64001
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of the first coding exon with a neomycin cassette. (J:64001)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Timp2 Mutation:  8 strains or lines available
References
Original:  J:64001 Wang Z, et al., TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem. 2000 Aug 25;275(34):26411-5
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory