Lmx1a^dr-J
Spontaneous Allele Detail

Summary

• Symbol: Lmx1a^dr-J
• Name: LIM homeobox transcription factor 1 alpha; dreher Jackson
• MGI ID: MGI:1888413
• Synonyms: sst^J
• Gene: Lmx1a Location: Chr1:167516806-167676310 bp, + strand Genetic Position: Chr1, 75.08 cM
• Alliance: Lmx1a^dr-J page

Mutation origin

• Strain of Origin: C3FeB6 A/A^w-J-Ank^ank/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-A transition mutation results in a conserved cysteine to a tyrosine amino acid change at position 82 (p.C82Y) in the LIM1 domain of the encoded protein. The conserved cysteine is thought to be required for coordination of zinc that is essential for the function of the LIM domain, and thus the transcriptional activity of the protein. (J:60593)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	36 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmx1a Mutation: 20 strains or lines available

References

• Original: J:13949 Sweet HO, et al., Shaker short-tail (sst). Mouse News Lett. 1983;69:26
• All: 29 reference(s)