All Phenotypes Lmx1a<dr-J> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lmx1a^dr-J/Lmx1a^dr-J	B6.Cg-Lmx1a^dr-J	MGI:2385675
hm2	Lmx1a^dr-J/Lmx1a^dr-J	C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J	MGI:3698429
hm3	Lmx1a^dr-J/Lmx1a^dr-J	involves: C3H * C57BL/6	MGI:3056800
hm4	Lmx1a^dr-J/Lmx1a^dr-J	involves: C3HeB/Fe * C57BL/6	MGI:4359812
ht5	Lmx1a^dr-J/Lmx1a⁺	B6.Cg-Lmx1a^dr-J	MGI:2385692
cn6	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	MGI:4359810
cx7	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Rjo	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6	MGI:4359809

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J
Genetic Background	B6.Cg-Lmx1a^dr-J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:63181 )

• Background Sensitivity: shorter life span than wild-type in original mixed background

• Background Sensitivity: in C57BL/6 background, no live-born homozygotes are generated

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J
Genetic Background	C3FeB6 A/A^w-J-Ank^ank Lmx1a^dr-J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:13949 )

• preweaning mortality is high

limbs/digits/tail

short tail ( J:13949 )

• a tiny filament at the tip of the tail seen at birth disappears by 2 days after birth leaving either a short tail or distinctly blunted tail

nervous system

abnormal cerebellar foliation ( J:13949 )

small cerebellum ( J:13949 )

behavior/neurological

abnormal righting response ( J:13949 )

• a delayed development of the righting reflex

hyperactivity ( J:13949 )

pigmentation

belly spot ( J:13949 )

• white belly spot and feet

reproductive system

infertility ( J:13949 )

integument

belly spot ( J:13949 )

• white belly spot and feet

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:63181 )

• Background Sensitivity: shorter life span than wild-type in original mixed background

• Background Sensitivity: initial breeding experiments in mixed background generated many live born homozygous pups

behavior/neurological

head tossing ( J:63181 )

circling ( J:63181 )

hearing/vestibular/ear

deafness ( J:63181 )

pigmentation

belly spot ( J:63181 )

• a complete white belt around trunk with some variability

nervous system

abnormal neuronal migration ( J:1460 )

• abnormal neuronal migration contributes to abnormal cerebellum development

spina bifida ( J:63181 )

• in vertebrae T9-T13

abnormal rhombomere morphology ( J:63181 )

• significant changes in the shape of rhombomeres 3, 4, and 5 are observed in homozygote embryos

• however, hindbrain segmentation and territories posterior to r6 are not affected

abnormal rhombomere 3 morphology ( J:63181 )

• r3 is deformed and bends posteriorly

abnormal rhombomere 4 morphology ( J:63181 )

• the dorsal/lateral domains of r4 are compressed or reduced in width

• however, the ventral region of r4 is normal, as shown by proper migration of the facial motor neurone population along the midline into r5

abnormal rhombomere 5 morphology ( J:63181 )

• r5 is broadened and not separated at the midline into two bilateral domains as seen in wild-type embryos

abnormal roof plate morphology ( J:63181 )

• defective roof plate formation in the hindbrain

abnormal hippocampus development ( J:1460 )

abnormal hippocampus CA3 region morphology ( J:1460 )

• pyramidal layer forms widely dispersed arrangements in this area

• there is aberrant cholinergic activity

abnormal hippocampus pyramidal cell layer ( J:1460 )

• forms widely dispersed arrangements in CA3 region

• there are ectopically located pyramidal cells in the stratum radiatum and stratum oriens

• abnormal acetylcholinesterase activity is found in the ectopic pyramidal cells

abnormal cerebellum morphology ( J:1460 )

abnormal cerebellum development ( J:1460 )

• the cerebellum is almost completely absent

abnormal cerebellar foliation ( J:1460 )

• disruptions in foliation are found

• there are mixtures of normal and abnormal laminated structure

• islands of both granule and Purkinje cells or just granule cells are observed

abnormal glossopharyngeal ganglion morphology ( J:63181 )

• much reduced glossopharyngeal ganglion

abnormal glossopharyngeal nerve morphology ( J:63181 )

• an accessory branch originating in the glossopharyngeal/vagus region projects abnormally

craniofacial

abnormal interparietal bone morphology ( J:63181 )

• the shape and ossification is severely disrupted

abnormal parietal bone morphology ( J:63181 )

• the shape of the parietal bone is affected

• highly disorganized lamboid suture

skeleton

abnormal interparietal bone morphology ( J:63181 )

• the shape and ossification is severely disrupted

abnormal parietal bone morphology ( J:63181 )

• the shape of the parietal bone is affected

• highly disorganized lamboid suture

abnormal vertebral arch development ( J:63181 )

• neural arches in C1 fail to form along the dorsal midline

• delay in fusion of the arches in C2 and C3

• failure in dorsal fusion of vertebrae T9-T13 causing grossly altered neural arches

synostosis ( J:63181 )

• occasional synostosis of the cranial vault along the interface of the interparietal and supraoccipital bone

• responsible for the blebbing on the head seen in live animals

cellular

abnormal cell physiology ( J:14476 )

• an abnormal distribution of acetylcholinesterase is found in the hippocampus

abnormal neuronal migration ( J:1460 )

• abnormal neuronal migration contributes to abnormal cerebellum development

abnormal cell proliferation ( J:1460 )

• disruption of cell proliferation contributes to abnormal cerebellum development

embryo

spina bifida ( J:63181 )

• in vertebrae T9-T13

abnormal rhombomere morphology ( J:63181 )

• significant changes in the shape of rhombomeres 3, 4, and 5 are observed in homozygote embryos

• however, hindbrain segmentation and territories posterior to r6 are not affected

abnormal rhombomere 3 morphology ( J:63181 )

• r3 is deformed and bends posteriorly

abnormal rhombomere 4 morphology ( J:63181 )

• the dorsal/lateral domains of r4 are compressed or reduced in width

• however, the ventral region of r4 is normal, as shown by proper migration of the facial motor neurone population along the midline into r5

abnormal rhombomere 5 morphology ( J:63181 )

• r5 is broadened and not separated at the midline into two bilateral domains as seen in wild-type embryos

abnormal roof plate morphology ( J:63181 )

• defective roof plate formation in the hindbrain

integument

belly spot ( J:63181 )

• a complete white belt around trunk with some variability

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J
Genetic Background	involves: C3HeB/Fe * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum development ( J:152673 )

• at E12.5, reduced proliferation is observed in the cerebellar anlage

Allelic Composition	Lmx1a^dr-J/Lmx1a⁺
Genetic Background	B6.Cg-Lmx1a^dr-J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:63181 )

• Background Sensitivity: in C57BL/6 background, a white patch of variable size in the coat on the belly

• Background Sensitivity: in C57BL/6 background, white spotting trait became fully penetrant

integument

belly spot ( J:63181 )

• Background Sensitivity: in C57BL/6 background, a white patch of variable size in the coat on the belly

• Background Sensitivity: in C57BL/6 background, white spotting trait became fully penetrant

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Zfc Tg(Lmx1a-cre)1Kjmi/0
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmx1a^dr-J mutation (1 available); any Lmx1a mutation (20 available)
Lmx1b^tm1Rjo mutation (0 available); any Lmx1b mutation (16 available)
Lmx1b^tm1Zfc mutation (0 available); any Lmx1b mutation (16 available)
Tg(Lmx1a-cre)1Kjmi mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal fourth ventricle morphology ( J:152673 )

• fourth ventricle roof plate size is dramatically smaller relative to wild-type or Lmx1a-null mice at E10.5

abnormal cerebellum morphology ( J:152673 )

• P20 mice show severe cerebellar defects

abnormal cerebellum development ( J:152673 )

• at E12.5, reduced proliferation is observed in the cerebellar anlage

small cerebellum ( J:152673 )

• cerebellum is reduced in size

Allelic Composition	Lmx1a^dr-J/Lmx1a^dr-J Lmx1b^tm1Rjo/Lmx1b^tm1Rjo
Genetic Background	involves: 129S7/SvEvBrd * C3HeB/Fe * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal fourth ventricle morphology ( J:152673 )

• rhombomere 1 roofplate is normal

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