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Tgfb2tm1Doe
Targeted Allele Detail
Nomenclature
Symbol: Tgfb2tm1Doe
Name: transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman
MGI ID: MGI:1888389
Synonyms: TGBbeta2-, Tgfb2-, TGF-beta2-
Gene: Tgfb2  Location: Chr1:186622792-186705989 bp, - strand  Genetic Position: Chr1, 89.95 cM
Thin cornea and iridocorneal dysgenesis in Ext1tm1Yama/Ext1+ H2afvTg(Wnt1-cre)11Rth/0 Tgfb2tm1Doe/Tgfb2+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41682
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 6 was disrupted by the insertion of a neomycin selection cassette. The insertion introduced stop codons in all three reading frames. RT-PCR analysis showed an absence of normal message in homozygous mutant mice. (J:41682)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 145 assay results
In Structures Affected by this Mutation: 75 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tgfb2 Mutation:  5 strains or lines available
Notes
Homozygotes exhibit a "Peters'-like" anomaly instead of an Axenfeld-Reiger's and Peter's anomaly (J:73681).
References
Original:  J:41682 Sanford LP, et al., TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development. 1997 Jul;124(13):2659-70
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory