About   Help   FAQ
Igh-Jtm1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm1Cgn
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, University of Cologne
MGI ID: MGI:1861941
Synonyms: Igh-JHdelta, JH-, JHT
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64285
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsDeletional recombination mediated by cre-loxP resulted in the loss of the exons encoding the joining region and the intron enhancer of the immunoglobulin heavy chain locus (IgH). (J:64285)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  11 strains or lines available
References
Original:  J:64285 Gu H, et al., Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993 Jun 18;73(6):1155-64
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory