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ShhDsh
Radiation induced Allele Detail
Nomenclature
Symbol: ShhDsh
Name: sonic hedgehog; short digits
MGI ID: MGI:1861186
Synonyms: Dsh, short digits
Gene: Shh  Location: Chr5:28456815-28467101 bp, - strand  Genetic Position: Chr5, 14.39 cM
Mutation
origin
Strain of Origin:  (101 x C3H)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Inversion
 
Mutation detailsThe short digits mutation was shown to be allelic to Shh mutations by an alleleism test (Stefan Mundlos, unpublished, see also J:67151). This mutation is an inversion comprising 11.7 Mb. The distal breakpoint is 13.298 kb upstream of Shh, separating the coding sequence from several putative regulatory elements. The inversion results in dysregulated expression of Shh resulting in the mutant phenotype. (J:97323)
Inheritance:    Semidominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 21 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Shh Mutation:  22 strains or lines available
References
Original:  J:14105 Selby P, et al., Short digits, a new mutation. Mouse News Lett. 1986;75:43
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/17/2015
MGI 5.21
The Jackson Laboratory