Tk1^tm1Vnd
Targeted Allele Detail

Summary

• Symbol: Tk1^tm1Vnd
• Name: thymidine kinase 1; targeted mutation 1, Vasily N Dobrovolsky
• MGI ID: MGI:1860251
• Synonyms: Tk -
• Gene: Tk1 Location: Chr11:117706352-117716918 bp, - strand Genetic Position: Chr11, 82.96 cM, cytoband E1-E2
• Alliance: Tk1^tm1Vnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42191
• Parent Cell Line: BK4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the 5' promoter region, first exon, first intron and a portion of exon 2 of Tk1 as well as the 5' promoter region, first exon and part of intron 1 of Afmid. (J:42191)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tk1 Mutation: 28 strains or lines available

References

• Original: J:42191 Dobrovolsky VN, et al., Development of a novel mouse tk+/- embryonic stem cell line for use in mutagenicity studies. Environ Mol Mutagen. 1996;28(4):483-9
• All: 10 reference(s)