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Tnfrsf11atm1Imx
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf11atm1Imx
Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, Immunex Research and Development Corporation
MGI ID: MGI:1860238
Synonyms: RANK-
Gene: Tnfrsf11a  Location: Chr1:105780718-105847981 bp, + strand  Genetic Position: Chr1, 49.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57899
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette was used to replace exons 4 through 7, which encode for the majority of both the extracellular domain and the transmembrane region. Southern blot analysis verified the targeting event. (J:57899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11a Mutation:  24 strains or lines available
Notes
ES cell line was not specified, but noted to be 129 derived.
References
Original:  J:57899 Dougall WC, et al., RANK is essential for osteoclast and lymph node development. Genes Dev. 1999 Sep 15;13(18):2412-24
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory