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Vpreb1tm1Ilm
Targeted Allele Detail
Nomenclature
Symbol: Vpreb1tm1Ilm
Name: pre-B lymphocyte gene 1; targeted mutation 1, Inga-Lill Martensson
MGI ID: MGI:1859923
Synonyms: VpreB1 -
Gene: Vpreb1  Location: Chr16:16868402-16870843 bp, - strand  Genetic Position: Chr16, 10.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53512
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAll of exon 1 and a portion of exon 2 were replaced with a neomycin selection cassette. RT-PCR analysis confirmed that while Vpreb1 transcript was absent in homozygous mutant mice, normal levels of Vpreb2 were present. (J:53512)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vpreb1 Mutation:  29 strains or lines available
References
Original:  J:53512 Martensson A, et al., Partial block in B lymphocyte development at the transition into the pre-B cell receptor stage in Vpre-B1-deficient mice. Int Immunol. 1999 Mar;11(3):453-60
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory