About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Vpreb1atm1Ilm
targeted mutation 1, Inga-Lill Martensson
MGI:1859923
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm B6.129P2-Vpreb1atm1Ilm MGI:3843023
hm2
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm involves: 129P2/OlaHsd * C57BL/6 MGI:2653710
cx3
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1btm1Ilm 		B6.129P2-Vpreb1atm1Ilm Vpreb1btm1Ilm MGI:3843017
cx4
 		Vpreb1atm1Ilm/Vpreb1a+
Vpreb1btm1Ilm/Vpreb1btm3Ilm 		involves: 129P2/OlaHsd * C57BL/6 MGI:3843020
cx5
 		Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3843022


Genotype
MGI:3843023
hm1
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Genetic
Background		 B6.129P2-Vpreb1atm1Ilm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 35%
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are enriched about 1.6 fold

hematopoietic system
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 35%
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are enriched about 1.6 fold




Genotype
MGI:2653710
hm2
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:53512 )
N
• allelic exclusion of IgH occurs normally
• good antibody response to T cell dependent antigens
arrested B cell differentiation ( J:53512 )
• accumulation of cells at the pre-BI stage, indicating a partial block at the transition from pre-BI to pre-BII cells (into the pre-BCR stage)
abnormal pre-B cell morphology ( J:53512 )
• percentage of pre-BI cells is increased and the percentage of pre-BII and immature B cells is slightly decreased

hematopoietic system
arrested B cell differentiation ( J:53512 )
• accumulation of cells at the pre-BI stage, indicating a partial block at the transition from pre-BI to pre-BII cells (into the pre-BCR stage)
abnormal pre-B cell morphology ( J:53512 )
• percentage of pre-BI cells is increased and the percentage of pre-BII and immature B cells is slightly decreased




Genotype
MGI:3843017
cx3
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1btm1Ilm
Genetic
Background		 B6.129P2-Vpreb1atm1Ilm Vpreb1btm1Ilm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Ilm mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:67609 )
N
• heavy chain allelic exclusion still occurs normally
• IgM levels are normal
abnormal B cell differentiation ( J:67609 )
• B220+ cells decreased to about half of control levels in bone marrow
• CD19+ cells reduced in numbers in bone marrow
• B220+ CD19- cell numbers are normal in bone marrow
abnormal immature B cell morphology ( J:67609 )
• number of IgM+ cells reduced 25 fold in young and 10 fold in old mice
• transformation from pre-BII to immature B cells is normal
decreased mature B cell number ( J:67609 )
• IgM+ cells reduced 25 fold in young and 10 fold in older mice
• similar reduction in IgM+ IgD+ mature B cells
decreased B-1a cell number ( J:67609 )
• numbers are reduced in 10-12 day old mice
• numbers return to normal by 9-13 weeks of age
• only B cell lineage to recover to normal numbers
decreased pre-B cell number ( J:67609 )
• pre-BII cells reduced about 40 fold in young mice (B220+ CD25+)
• pre-BII cells reduced about 10 fold in older mice
• ratio of large to small pre-BII cells is about 1:1 or 1:1.5 compared to 1:4 in controls
• 5 fold reduction in large and 15 fold reduction in small pre-BII cells
• defective proliferative expansion of pre-BII cells
• decreased large pre-BII cells with further reduction of small pre-BII cells
increased pre-B cell number ( J:67609 )
• pre-BI cell numbers are increased about 2 fold in bone marrow (B220+, c-Kit+)
• CD19+, c-Kit+ cells also increased about 2 fold
abnormal splenic cell ratio ( J:67609 )
• total nucleated cells reduced to about 70% in young and 45% in older mice
• B cell numbers increase with age, mostly as mature cells
decreased IgG level ( J:67609 )
• slightly decrease IgG antibody response

hematopoietic system
abnormal B cell differentiation ( J:67609 )
• B220+ cells decreased to about half of control levels in bone marrow
• CD19+ cells reduced in numbers in bone marrow
• B220+ CD19- cell numbers are normal in bone marrow
abnormal immature B cell morphology ( J:67609 )
• number of IgM+ cells reduced 25 fold in young and 10 fold in old mice
• transformation from pre-BII to immature B cells is normal
decreased bone marrow cell number ( J:67609 )
• slight decrease in nucleated bone marrow cells at 10 days of age
• decreased number of nucleated bone marrow cells becomes more prominent after 50 days of age
decreased mature B cell number ( J:67609 )
• IgM+ cells reduced 25 fold in young and 10 fold in older mice
• similar reduction in IgM+ IgD+ mature B cells
decreased B-1a cell number ( J:67609 )
• numbers are reduced in 10-12 day old mice
• numbers return to normal by 9-13 weeks of age
• only B cell lineage to recover to normal numbers
decreased pre-B cell number ( J:67609 )
• pre-BII cells reduced about 40 fold in young mice (B220+ CD25+)
• pre-BII cells reduced about 10 fold in older mice
• ratio of large to small pre-BII cells is about 1:1 or 1:1.5 compared to 1:4 in controls
• 5 fold reduction in large and 15 fold reduction in small pre-BII cells
• defective proliferative expansion of pre-BII cells
• decreased large pre-BII cells with further reduction of small pre-BII cells
increased pre-B cell number ( J:67609 )
• pre-BI cell numbers are increased about 2 fold in bone marrow (B220+, c-Kit+)
• CD19+, c-Kit+ cells also increased about 2 fold
abnormal splenic cell ratio ( J:67609 )
• total nucleated cells reduced to about 70% in young and 45% in older mice
• B cell numbers increase with age, mostly as mature cells
decreased IgG level ( J:67609 )
• slightly decrease IgG antibody response




Genotype
MGI:3843020
cx4
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1a+
Vpreb1btm1Ilm/Vpreb1btm3Ilm
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Ilm mutation (0 available); any Vpreb1b mutation (8 available)
Vpreb1btm3Ilm mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:104211 )
N
• development of B cells in bone marrow is normal




Genotype
MGI:3843022
cx5
Allelic
Composition		 Vpreb1atm1Ilm/Vpreb1atm1Ilm
Vpreb1btm1Ilm/Vpreb1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vpreb1atm1Ilm mutation (0 available); any Vpreb1a mutation (24 available)
Vpreb1btm1Ilm mutation (0 available); any Vpreb1b mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:104211 )
• B220+ IgM+ cells reduced about 75%
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 75%
• ratio of large to small pre-BII cells is normal
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are increased about 2 fold

hematopoietic system
decreased mature B cell number ( J:104211 )
• B220+ IgM+ cells reduced about 75%
decreased pre-B cell number ( J:104211 )
• pre-BII cells reduced about 75%
• ratio of large to small pre-BII cells is normal
increased pre-B cell number ( J:104211 )
• pre-BI cell numbers are increased about 2 fold




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory