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Trim28tm1.2Ipc
Targeted Allele Detail
Nomenclature
Symbol: Trim28tm1.2Ipc
Name: tripartite motif-containing 28; targeted mutation 1.2, Pierre Chambon
MGI ID: MGI:1859550
Synonyms: L-, Tif1b-, TIF1beta-
Gene: Trim28  Location: Chr7:12999114-13031035 bp, + strand  Genetic Position: Chr7, 7.73 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62628
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsDeletion of exons 4-14 of the coding region as follows: A PGK-neomycin cassette flanked by two loxP sites was introduced into intron 3 and a loxP site was introduced into exon 14. Mice positive for the presence of this allele were mated to CMV-Cre transgenic mice to generate mice in which the loxP flanked sequences were deleted. (J:62628)
Inheritance:    Recessive
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 5 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim28 Mutation:  23 strains or lines available
References
Original:  J:62628 Cammas F, et al., Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development. 2000 Jul;127(13):2955-63
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory