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Msh5tm1Rak
Targeted Allele Detail
Nomenclature
Symbol: Msh5tm1Rak
Name: mutS homolog 5; targeted mutation 1, Raju Kucherlapati
MGI ID: MGI:1858057
Synonyms: Msh-, Msh5-
Gene: Msh5  Location: Chr17:35028605-35046745 bp, - strand  Genetic Position: Chr17, 18.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51921
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA hygromycin resistance gene was inserted into exon 18, at codon 528, of the gene. No transcript for the targeted gene was detected on Northern blots of RNA extracted from testes of homozygous mutant mice. No protein product for the targeted gene was detected on Western blots of protein extracted from testes of homozygous mutant mice. (J:51921)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Msh5 Mutation:  29 strains or lines available
References
Original:  J:51921 Edelmann W, et al., Mammalian MutS homologue 5 is required for chromosome pairing in meiosis. Nat Genet. 1999 Jan;21(1):123-7
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory