About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh5tm1Rak
targeted mutation 1, Raju Kucherlapati
MGI:1858057
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msh5tm1Rak/Msh5tm1Rak involves: 129/Sv * C57BL/6J * SJL MGI:2183396
cx2
 		Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak 		involves: 129/Sv * C57BL/6 * SJL MGI:2663948


Genotype
MGI:2183396
hm1
Allelic
Composition		 Msh5tm1Rak/Msh5tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh5tm1Rak mutation (1 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ovary cyst ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
ovary degeneration ( J:51921 )
• normal in size at birth, but degenerate progressively to become rudimentary by adulthood
small testis ( J:51921 )
• 70% reduction in size

reproductive system
decreased oocyte number ( J:51921 )
• oocyte numbers declined steadily with degeneration of ovaries
ovary cyst ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
ovary degeneration ( J:51921 )
• normal in size at birth, but degenerate progressively to become rudimentary by adulthood
small testis ( J:51921 )
• 70% reduction in size
abnormal male meiosis ( J:51921 , J:62204 )
• abnormal chromosomal pairing (J:51921)
(J:62204)

growth/size/body
ovary cyst ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts
abnormal ovarian bursa morphology ( J:51921 )
• by adulthood, ovarian bursa are empty or frequently contain cystic structures with 1-4 cysts

cellular
decreased oocyte number ( J:51921 )
• oocyte numbers declined steadily with degeneration of ovaries




Genotype
MGI:2663948
cx2
Allelic
Composition		 Msh4tm1Wed/Msh4tm1Wed
Msh5tm1Rak/Msh5tm1Rak
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh4tm1Wed mutation (0 available); any Msh4 mutation (39 available)
Msh5tm1Rak mutation (1 available); any Msh5 mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:62204 )
• abnormal chromosomal pairing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory