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Spontaneous Allele Detail
Symbol: CrygdLop12
Name: crystallin, gamma D; lens opacity 12
MGI ID: MGI:1858026
Synonyms: Lop12
Gene: Crygd  Location: Chr1:65061872-65063452 bp, - strand  Genetic Position: Chr1, 32.8 cM
Strain of Origin:  BALB/cJ x SJL/J
Allele Type:    Spontaneous
Mutation:    Single point mutation
Mutation detailsA G-to-A transition at nucleotide position 470 in exon 3 creates a premature termination signal and results in a truncated protein after amino acid 156. (J:60856)
Inheritance:    Semidominant
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crygd Mutation:  2 strains or lines available
Both homozygous and heterozygous mutant mice develop cataracts by one month of age. The catarats demonstrate prominent reactive fibrous proliferation surrounding extruded lens cortical fragments, accompanied by focal, mild lymphocytic infiltration. Homozygous mice have eyes that are smaller than wildtype, whereas the heterozygote mouse has an eye size that is intermediate (J:60856).

Original:  J:60856 Smith RS, et al., Lop12, a mutation in mouse Crygd causing lens opacity similar to human Coppock cataract. Genomics. 2000 Feb 1;63(3):314-20
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory