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Targeted Allele Detail
Symbol: Tal1tm2Wehi
Name: T cell acute lymphocytic leukemia 1; targeted mutation 2, Walter and Eliza Hall, Institute of Medical Research
MGI ID: MGI:1858004
Synonyms: Scl-, SCLlacZ, SCL-lacZ
Gene: Tal1  Location: Chr4:115056426-115071755 bp, + strand  Genetic Position: Chr4, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:50149
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsInsertion of a lacZ reporter gene into the 5' untranslated region of the gene. This mutation also deletes all coding sequences. (J:50149)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 53 assay results
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tal1 Mutation:  20 strains or lines available
Original:  J:50149 Elefanty AG, et al., Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ knock-in strategy. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11897-902
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory