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Myf5tm1Pas
Targeted Allele Detail
Nomenclature
Symbol: Myf5tm1Pas
Name: myogenic factor 5; targeted mutation 1, Institut Pasteur
MGI ID: MGI:1857973
Synonyms: myf-5a2, Myf5lacZ, myf-5/nlacZ, Myf5-nlacZ
Gene: Myf5  Location: Chr10:107482908-107486134 bp, - strand  Genetic Position: Chr10, 55.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36716
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsAn nLacZ gene is fused in-frame to the DNA sequences encoding the first 13 amino acids, resulting in a disruption of the gene and expression of nLacZ under the transcriptional regulation of the endogenous promoter. A neomycin resistance cassette, RNA polymerase II promoter and 3' sequence of the HPRT gene were introduced after the reporter gene. (J:36716, J:39308, J:92799)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 198 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myf5 Mutation:  6 strains or lines available
References
Original:  J:36716 Tajbakhsh S, et al., Muscle progenitor cells failing to respond to positional cues adopt non-myogenic fates in myf-5 null mice. Nature. 1996 Nov 21;384(6606):266-70
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/30/2021
MGI 6.16
The Jackson Laboratory