Phenotypes associated with this allele

• Allele Symbol: Myf5^tm1Pas
• Allele Name: targeted mutation 1, Institut Pasteur
• Allele ID: MGI:1857973
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf5^tm1Pas/Myf5^tm1Pas	involves: 129 * C57BL/6 * DBA/2	MGI:3055411
hm2	Myf5^tm1Pas/Myf5^tm1Pas	Not Specified	MGI:2170514
cx3	Myf5^tm1Pas/Myf5^+ Myod1^tm1Jae/Myod1^tm1Jae	involves: 129 * C57BL/6 * DBA/2	MGI:3055415
cx4	Myf5^tm1Pas/Myf5^tm1Pas Myod1^tm1Jae/Myod1^tm1Jae	involves: 129 * C57BL/6 * DBA/2	MGI:3055413
cx5	Myf5^tm1Pas/Myf5^tm1Pas Myod1^tm1Jae/Myod1^+	involves: 129 * C57BL/6 * DBA/2	MGI:3055414

Genotype
MGI:3055411

hm1

• Allelic Composition: Myf5^tm1Pas/Myf5^tm1Pas
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

absent myotome ( J:92799 )

• at E10 early myotome is missing

abnormal skeletal muscle morphology ( J:92799 )

• dorsal muscles are absent

cellular

abnormal muscle precursor cell migration ( J:92799 )

• muscle progenitor cells are abnormally located along the epaxial-most and hypaxial-most dermomyotome lips

Genotype
MGI:2170514

hm2

• Allelic Composition: Myf5^tm1Pas/Myf5^tm1Pas
• Genetic Background: Not Specified

muscle

absent extraocular muscles ( J:150130 )

• at birth, mice completely lack extraocular muscles or only have residual myofibers unlike in wild-type mice

abnormal eye muscle development ( J:150130 )

• by E11.5, the extraocular muscle anlage fails to pattern and begins to atrophy unlike in wild-type mice

• extraocular muscle anlagen exhibits a 5- to 6-fold increase in apoptotic cells compared to in wild-type mice

embryo

delayed somite formation ( J:150130 )

• at E11.5, somatic muscle progenitor cells exhibit a temporary pause in development but do not apoptose

• however, somite fate is rescued thereafter by Myod1 expression

vision/eye

absent extraocular muscles ( J:150130 )

• at birth, mice completely lack extraocular muscles or only have residual myofibers unlike in wild-type mice

abnormal eye muscle development ( J:150130 )

• by E11.5, the extraocular muscle anlage fails to pattern and begins to atrophy unlike in wild-type mice

• extraocular muscle anlagen exhibits a 5- to 6-fold increase in apoptotic cells compared to in wild-type mice

Genotype
MGI:3055415

cx3

• Allelic Composition: Myf5^tm1Pas/Myf5⁺; Myod1^tm1Jae/Myod1^tm1Jae
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

mortality/aging

postnatal lethality ( J:92799 )

Genotype
MGI:3055413

cx4

• Allelic Composition: Myf5^tm1Pas/Myf5^tm1Pas; Myod1^tm1Jae/Myod1^tm1Jae
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

mortality/aging

postnatal lethality, complete penetrance ( J:92799 )

• double homozygous mutants display postnatal lethality

muscle

abnormal myogenesis ( J:92799 )

• no skeletal myogenesis is seen at any developmental stage

absent skeletal muscle ( J:92799 )

• mutants lack skeletal muscle throughout the body including the head

Genotype
MGI:3055414

cx5

• Allelic Composition: Myf5^tm1Pas/Myf5^tm1Pas; Myod1^tm1Jae/Myod1⁺
• Genetic Background: involves: 129 * C57BL/6 * DBA/2

mortality/aging

postnatal lethality ( J:92799 )