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Apex1tm1Cur
Targeted Allele Detail
Nomenclature
Symbol: Apex1tm1Cur
Name: apurinic/apyrimidinic endonuclease 1; targeted mutation 1, Tom Curran
MGI ID: MGI:1857956
Synonyms: ref-1 -
Gene: Apex1  Location: Chr14:50924968-50927139 bp, + strand  Genetic Position: Chr14, 26.3 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34891
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA genomic fragment containing exons 1-4 was replaced with a neomycin (NEO) cassette driven by phosphoglycerate kinase (PGK) promoter. (J:34891)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apex1 Mutation:  12 strains or lines available
References
Original:  J:34891 Xanthoudakis S, et al., The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8919-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory