Analysis Tools|
Allele Symbol Allele Name Allele ID |
Apex1tm1Cur targeted mutation 1, Tom Curran MGI:1857956 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die prior to E6.5
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• mice are unable to develop beyond implantation
• however, cultured blastocysts exhibit normal growth and hatching
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• under anesthetized conditions
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• vascular smooth muscle cells exhibit increased apoptosis in response to Fas ligand compared with wild-type cells
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• in response to phenylephrine with L-NAME
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• in response to phenylephrine
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• in response to acetycholine
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• mice exhibit reduced neointimal hyperplasia in response to femoral artery wire injury compared to similarly treated wild-type mice
• mice fail to exhibit an increase in IL10 and IL1a levels following injury compared with similarly treated wild-type mice
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• mice exhibit reduced neointimal hyperplasia in response to femoral artery wire injury compared to similarly treated wild-type mice
• mice fail to exhibit an increase in IL10 and IL1a levels following injury compared with similarly treated wild-type mice
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• prior to injury
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• prior to injury
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• basal serum nitric oxide metabolites compared with wild-type mice
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• mice exhibits reduced vasodilation in response to acetylcholine and altered vascular tone in response to phenylephrine with or without L-NAME compared with wild-type mice
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• prior to injury
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• prior to injury
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• vascular smooth muscle cells exhibit increased apoptosis in response to Fas ligand compared with wild-type cells
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• in response to phenylephrine with L-NAME
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• in response to phenylephrine
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• in response to acetycholine
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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