About   Help   FAQ
Bmp8btm1Blh
Targeted Allele Detail
Nomenclature
Symbol: Bmp8btm1Blh
Name: bone morphogenetic protein 8b; targeted mutation 1, Brigid L Hogan
MGI ID: MGI:1857954
Gene: Bmp8b  Location: Chr4:123105165-123132099 bp, + strand  Genetic Position: Chr4, 57.38 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34057
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 7 kb genomic fragment containing exon 4 was replaced with a neomycin selection cassette. The deleted sequences encode the conserved dibasic proteolytic cleavage site between the pro- and mature regions of the encoded protein. In situ hybridization experiments on sections of testis of homozygous male mice confirmed that no detectable transcript was produced from this allele. (J:34057)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bmp8b Mutation:  4 strains or lines available
Notes
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or TL1 (129S6/SvEvTac).

References
Original:  J:34057 Zhao GQ, et al., The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Genes Dev. 1996 Jul 1;10(13):1657-69
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory