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Bmp2tm1Brd
Targeted Allele Detail
Nomenclature
Symbol: Bmp2tm1Brd
Name: bone morphogenetic protein 2; targeted mutation 1, Allan Bradley
MGI ID: MGI:1857894
Synonyms: bmp2m1
Gene: Bmp2  Location: Chr2:133552159-133562885 bp, + strand  Genetic Position: Chr2, 65.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36213
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn HPRT mini-gene cassette replaced a 4.0 kb genomic fragment that contains sequences encoding the entire BMP2 mature region and two thirds of the propeptide. (J:36213)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp2 Mutation:  8 strains or lines available
References
Original:  J:36213 Zhang H, et al., Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 1996 Oct;122(10):2977-86
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory