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Oas1bFlv-r
Spontaneous Allele Detail
Nomenclature
Symbol: Oas1bFlv-r
Name: 2'-5' oligoadenylate synthetase 1B; flavivirus resistance
MGI ID: MGI:1857800
Synonyms: Flvr
Gene: Oas1b  Location: Chr5:120950700-120962228 bp, + strand  Genetic Position: Chr5, 60.64 cM, cytoband F
Mutation
origin
Strain of Origin:  various
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation detailsThis allele confers resistance to flavivirus infection. Susceptible mouse strains produce a protein lacking 30% of the C-terminal region due a nucleotide substitution. The T-to-C transition in resistant strains results in the change of a premature stop codon to an arginine codon at position 253 (p.*253R). (J:77001)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Oas1b Mutation:  9 strains or lines available
Notes
The majority of mouse strains carry the susceptibility allele. Only the Det, BSVR, BRVR, CASA/RK, CAST/Ei, and PRI carry the resistance allele. The MOLD/Rk strain carried the allele for minor resistance.

Genbank ID for this allele: AF481734

References
Original:  J:15009 Sabin AB, Nature of inherited resistance to viruses affecting the nervous system. Proc Natl Acad Sci U S A. 1952 Jun;38(6):540-46
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/12/2021
MGI 6.17
The Jackson Laboratory