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Tlr4Lps-d
Spontaneous Allele Detail
Nomenclature
Symbol: Tlr4Lps-d
Name: toll-like receptor 4; defective lipopolysaccharide response
MGI ID: MGI:1857718
Synonyms: lpsd, mutant TLR4, Tlr4-, Tlr4d, TLR4d, TLR4lps-def, TLR4-M, TLR4-Mu, TlrLps-d
Gene: Tlr4  Location: Chr4:66827584-66930284 bp, + strand  Genetic Position: Chr4, 34.66 cM
ru2l/ru2l Tlr4Lps-d/Tlr4Lps-d with littermate control

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C3H/HeJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Single point mutation
 
Mutation details
Inheritance:    Codominant
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 1 line available
Carrying any Tlr4 Mutation:  24 strains or lines available
Notes
C3H/HeJ mice carry this allele. Various combinations of Lps-associated traits have been followed in crosses between C3H/HeJ and other C3H substrains, and the traits have in all cases segregated together (J:30692, J:5557, J:5593, J:5938). Some of the traits show dominance of the Tlr4lps-n allele; others, including Tlr4Lps-d, show codominance.

Genbank ID for this allele: AF095353

References
Original:  J:5721 Dumont F, et al., Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/Hej mice. Folia Biol (Praha). 1976;12(3):145-50
All:  305 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory